UMass Chan Medical School
Zebrafish are helpful models for studying skin conditions like vitiligo and melanoma.
In a July 2023 article featured on The Conversation, Craig Creol, Ph.D., Assistant Professor, Program in Molecular Medicine, UMass Chan Medical School, discusses his 20 years studying melanocytes and the role these cells play in disease.
What are melanocytes?
Melanocytes are a small subset of epidermal cells that play an outsize role in protecting the skin from the damaging effects of sun exposure. A shortage of working melanocytes causes many skin conditions, including skin cancer and vitiligo.
Unlike melanocytes in mice or human skin, zebrafish melanocytes are externally visible. Since melanocyte stem cells in zebrafish are externally visible, Creol tracked these cells in real time to see how they divided and matured.
"The unique features of zebrafish have allowed us to uncover a new mode of cellular regeneration. Because of cross-species similarities, we expect that these and many other findings from research using zebrafish may be applied to human biology."
Discover how research using zebrafish may be applied to human biology.